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Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites (108)

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Journal of Cachexia, Sarcopenia and Muscle, 15 (3), 1072-1083.

However, reduced GLP-1/Notch activity causes all GSCs to cease self-renewal/germline proliferation and differentiate as sperm (Glp phenotype) (Fig