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Therefore, genetic depletion of TXN and TXNDR1 with siRNA oligonucleotides disrupts the redox balance mediated by the Trx system in tumor cells, thereby contributing to the inhibition of cell proliferation

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Similarly, in murine MASH models, loss of CD103 + cDC1 exacerbated steatosis and lobular inflammation, whereas adoptive transfer of these cells reduced hepatic CCL2 expression and monocyte recruitment (77) ( Figure 3C )

The plasmids generated in the work have been deposited to Addgene

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Immune System A strong immune system depends on balanced inflammation, efficient detoxification, and cellular defense mechanisms