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Aside from the polymorphism, there also exists acquired glutathione synthetase deficiency because the enzyme may not perform equally well across the persons life span

Melatonin is involved in scavenging hypochlorous acid and deactivating chemical agents such as H 2 O 2 , OH*, peroxyl radical, and reactive nitrogen species through electron donation, hydrogen donation, addition, substitution, and nitrosation, thus preventing oxidative stress

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This makes IV glutathione a great choice for people with low glutathione levels