Zaman GJ, Lankelma J, van Tellingen O, Beijnen J, Dekker H, Paulusma C et al
This article presents a study in which a prediction model for BE based on GERD, age, abdominal obesity and cigarette use with an AUC of 0.72 is developed in 822 male patients with colorectal cancer who are screened using upper endoscopy
Factors such as neuronal damage in the brain, inflammatory responses, oxidative stress, cell death, and altered neuroplasticity can influence depression (Malhi and Mann, 2018)
proposed that a the phospholipid/Ca++ dependent brain pkc participated in the expression of neuroplasticity and demonstrated this effect using the phorbol acetate TPA to enhance the action of pkc to maintain LTP in rat hipoccampal neurons (Routtenberg et al., 1986), in effect, producing a a long-lasting potentiation of synaptic activation (Nogus, 1997)
SnapShot: the microbiota-gut-brain axis
In preclinical studies, BPC-157 demonstrated an exceptionally wide therapeutic window with no observed toxicity even at high doses. Sikiric et al., Current Pharmaceutical Design Long-Term Safety As of now, long-term human safety data is lacking
