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(PubMed) Hansen RD, Albieri V, Tjonneland A, Overvad K, Andersen KK, Raaschou-Nielsen O

In FRDA mouse models, LONP1 protein levels progressively increase during disease progression, accompanied by enhanced proteasome activity and reduced mitochondrial Fe-S protein levels, while Fe-S mRNA expression remains unchanged

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Whether declining MOTS-c is a cause or consequence of this deterioration is still being resolved, but the correlation is striking enough that some researchers have proposed plasma MOTS-c as a biomarker of mitochondrial vitality and metabolic age

In mouse models of highfat dietinduced obesity, it treatment significantly reduced mRNA and protein expression of TNF, IL6, and other inflammatory factors in adipose tissue and decreased macrophage infiltration - a hallmark of adipose inflammation