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These findings further support the contributions of ATGs to the development of chemoresistance in cancer cells

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Myeloid LPCAT3 deficiency disrupts AA homeostasis in the liver, leading to metabolic imbalances and triglyceride accumulation ( 4.1.2 System Xc -/GSH/GPX4 pathway Ferroptosis is mainly induced by inhibiting glutathione production, with the System Xc -/GSH/GPX4 pathway playing a key role in preventing LPO

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1 21% fewer MACE events with RYBELSUS vs placeboboth in addition to standard of care which helped establish no increased risk of MACE ( P =0.17, NS) 3 a Treatment arms included patients taking either RYBELSUS or placebo who were either treatment nave or taking oral antidiabetics (OADs) and/or insulin