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When B12 is insufficient, these pathways slow down

Because of these multiple modes of action, curcumin is used clinically to treat a wide variety of conditions and diseases, including arthritis, diabetes, depression, cognitive decline, and autoimmunity, to name just a few

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Oncoimmunology 7:e1391972 Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R et al (1999) Anti-cancer activity of targeted pro-apoptotic peptides