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10.1016/j.neuro.2022.03.005 117 ZhouY.ZhengJ.LiY.XuD

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Its use outside of controlled research settings carries inherent risks related to compound purity, dosing accuracy, and the absence of the clinical safety monitoring that accompanies approved medications

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The doses administered to the rats were calculated using the US Food and Drug Administration guidelines for human equivalence doses (HED), assuming a human weight of 60 kg (Nair et al., 2016)