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Cardiovascular safety and benefits of semaglutide in patients with type 2 diabetes: Findings from SUSTAIN 6 and PIONEER 6

Wegovy (semaglutide) is a GLP-1 receptor agonist licensed for chronic weight management in adults and adolescents with obesity

Right now, researchers are looking at how well retatrutide works, how safe it is over time, and what the best ways to use it might be

GLP-1 receptors are widely distributed in other areas of the body, including the brain, gut, and kidneys, as well as the cardiovascular and immune systems, says Diana Isaacs, PharmD, an endocrine clinical pharmacy specialist at the Endocrine and Metabolism Institute at Cleveland Clinic in Ohio

This effect is transient with single doses but may become sustained with chronic receptor activation

It was revealed that fumarate, possessing a weak electrophilic property, modifies KEAP1 cysteine residues, resulting in the stabilization of NRF2