The definition of free radicals is uncharged molecules (typically highly reactive and short-lived) having an unpaired valence electron. According to the Pharmacognosy Review , reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. Free radicals can be very harmful, but their production within the body is certainly not abnormal or even entirely bad
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Dong XX, Wang Y, Qin ZH (2009) Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases