the effects of testosterone on long-term bone metabolism are unclear, but are expected to have at least a protective effect on existing bone mass over time by preventing unwanted increases in bone turnover that are frequently associated with osteoporosis
Medical evaluation Lab testing may be recommended to evaluate metabolic function, hormone levels, kidney and liver health, and inflammation markers
Evid Based Ment Health 2019
Evidence Summary: What the Data Suggest Several phase 2 and observational studies highlight the hepatic benefits of GLP1based treatment: Reduced liver fat: Repeated findings in imaging-based studies support this effect Lower liver enzymes: Consistent reductions in ALT/AST levels Fibrosis improvement: Promising trends in noninvasive markers, though further trials are needed While the strongest evidence comes from patients with obesity or type 2 diabetes, benefits in leaner, metabolically abnormal patients are increasingly documented, suggesting broader utility
This age-related vulnerability likely underlies why LLD is more common, heterogeneous and more difficult to treat than depression earlier in life
(August 2005)