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Dudiak, C

Macrophage migration inhibitory factor (MIF) is essential for inflammatory and neuropathic pain and enhances pain in response to stress

Regardless, supplementing with probiotics and prebiotics are a great way to restore gut flora and improve overall health

However, many subjects have difficulty achieving the required circulating levels of 25(OH)VD even after high-dose VD supplementation, and randomized controlled clinical trials have reported limited therapeutic success post-VD supplementation

While the medication itself does not require tapering from a pharmacological standpoint, the clinical context surrounding discontinuationparticularly the management of underlying conditions like diabetes or obesitydemands careful planning and medical supervision to ensure patient safety and optimize long-term health outcomes