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Without structured resistance exercise, a substantial portion of the weight lost on a GLP-1 medication will be muscle rather than fat leaving the person lighter but weaker, with reduced metabolic capacity and a higher risk of functional decline, particularly in older adults

Many studies have found no significant changes in basal or stimulated cortisol levels with GLP-1 therapy

Individual response magnitude varies widely based on genetic, metabolic, and lifestyle factors

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for someone with ME/CFS or Long COVID, it can happen while simply taking a warm shower, folding laundry, or walking up a single flight of stairs