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Clinical trials further provide proof-of-concept: Vitamin B12 supplementation markedly improves symptom severity and anxiety in patients with FM, consistent with restoration of one-carbon flux and normalization of methylation-dependent pathways

Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4)

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When GPx levels are low, the body cannot effectively neutralize hydrogen peroxide and other reactive oxygen species