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Although glutathione has limited oral bioavailability due to gastrointestinal degradation, studies show that orally administered GSH can still elevate tissue glutathione levels and improve antioxidant defence

The anticonvulsant drugs phenobarbital, phenytoin (Dilantin), and carbamazepine (Tegretol) may also lower plasma vitamin E concentrations in individuals with epilepsy (129)

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In our study, we observed that Cx32 levels decreased within 1 h in APAP-treated wild-type mice, whereas in hepsin-/- mice, this reduction occurred at 2 h post-treatment (Fig