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87 It has been shown that adiponectin increases insulin sensitivity in the liver and skeletal muscle, which is thought to be due to its ability to increase lipid and glucose metabolism

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The process includes: Release of GHRH from the hypothalamus Stimulation of GH secretion from the pituitary gland Conversion of GH into IGF-1 in the liver IGF-1 (insulin-like growth factor 1) is responsible for many of the downstream effects associated with growth hormone signaling, including tissue growth and metabolic regulation