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The last big factor when it comes to answering that question is your basal metabolic rate

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Unlike many experimental NRF2 activators (e.g., synthetic electrophiles or natural compounds like sulforaphane), DMF has undergone extensive Phase III trials, demonstrating its efficacy and safety in humans

Integr Biol 2011

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Gamma-H2AX, generated from the rapid phosphorylation of H2AX histone protein at the serine-139 position in early response to a broad range of DNA lesions, is a highly effective biomarker for DNA strand breaks and DNA oxidation and plays a central role in sensing and repairing DNA damage [52,53,54]