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Gdy tkanka zostaje uszkodzona przez uraz, stan zapalny lub stres oksydacyjny biaka macierzy pozakomrkowej (w szczeglnoci kolagen i SPARC) ulegaj rozpadowi, uwalniajc fragmenty peptydowe, w tym GHK
It also induced pathological changes, including severe congestion of the renal tissue with marked inflammation, interstitial edema, necrosis and glomerulosclerosis, as well as many ultrastructural changes in the kidney of rats 6
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