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This consistency suggests that the half-life provides continuous pharmacologic coverage, preventing the rebound hunger or cravings that can occur with shorter-acting agents

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The subcutaneous layer contains fat deposits, while the dermis consists of connective tissue

That shift in the clinical picture is what makes documentation (lab values, imaging, elastography) the practical lever for getting evaluated and, where appropriate, treated

Still, numbers alone do not tell the whole story

Several situations warrant pausing at a dose level for additional weeks before escalating: Persistent nausea: If nausea lasts beyond 2 weeks at any dose level, stay at that dose for an additional 2 to 4 weeks