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large-cohort studies indicated that the prevalence of subclinical depression ranges from 1 to 17% ( Ketamine is endowed with a peculiar profile with multiple pharmacological activities that may result from different underlying mechanisms

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J Toxicol Clin Toxicol 22(1):3149 Madejczyk MS, Aremu DA, Simmons-Willis TA, Clarkson TW, Ballatori N (2007) Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein

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Alternatively, if the acidosis fails to respond to N-acetylcysteine, this indicates the need to search further for alternative diagnoses