Maintaining the redox balance Oxidative stress is defined by an imbalance between oxidants and antioxidants, which arises from the excessive generation of ROS and a decrease in the rate of their elimination by the antioxidant defense system
As such, many putative target genes of NRF2 still require full validation, including chromatin immunoprecipitation (ChIP)-based identification of NRF2-ARE binding and mutation of putative AREs to ensure functionality as well as determination of their (patho)physiological relevance
This oxidative stress damages cellular membranes, nucleic acids, and proteins, ultimately leading to the apoptosis and necrosis of pancreatic cells (103)
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Diabetologia 2016;59:15581568 [DOI] [PMC free article] [PubMed] [Google Scholar] 120
Mitigation of risk by the higher intake of nutrient was considered significant if the estimate of was negative and statistically significant ( p 90th percentiles
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