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Moreover, cardiometabolic effects of GLP-1 are attenuated in obesity and T2D, via mechanisms that may involve impaired p38-MAPK signaling

doi: 10.1177/2164957X17735826

Our preferred GLP-1 medication at our weight loss clinic is tirzepatide because it mimics both the GLP hormone and the glucose-dependent insulinotropic polypeptide (GIP), which further regulates your appetite and blood sugar