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Mahad et al., 2008), excitotoxic mechanisms (Armada-Moreira et al., 2020), and the intimate relationship between misfolded protein aggregates and innate inflammation that can further exacerbate tissue injury (Joshi et al., 2014

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It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies