In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) 30 kg/m 2 ] or overweight (BMI 27 kg/m 2 ) with at least one weight-related comorbidity
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61 Activation of GLP-1 and GIP receptors stimulates insulin secretion from pancreatic beta cells in response to postprandial elevation in plasma glucose, and this effect is markedly attenuated under normoglycemic conditions, thereby mitigating the risk of hypoglycemia associated with GLP-1RAs therapy
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