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In addition, the choice of animal age is also very important because we need to select experimental animals that represent an age that is similar to human adults

However, intake levels often fall short of this recommendation, with the average intake in the US being around 8.6 mg/day for men and 7.3 mg/day for women over 50

Changes in opioid receptor expression, especially MOR, reduce the inhibitory function and efficiency of endogenous opioid peptides when the body responds to nociceptive stimuli, enhances neuronal excitability, and promotes the occurrence of sensory sensitization and the development of NP [81,103]

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Its molecular mass is 873 Daltons, making it a small, stable compound that researchers have studied extensively since the early 1980s