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In some embodiments, the practical osmolality of an otic formulation described herein is from about 100 mOsm/kg to about 1000 mOsm/kg, from about 200 mOsm/kg to about 800 mOsm/kg, from about 250 mOsm/kg to about 500 mOsm/kg, or from about 250 mOsm/kg to about 320 mOsm/kg, or from about 250 mOsm/kg to about 350 mOsm/kg or from about 280 mOsm/kg to about 320 mOsm/kg

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It is possible that under specific environmental or nutritional conditions, these variants may confer subtle adaptive advantagesan idea that warrants further exploration through longitudinal and mechanistic studies

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(2021) studied intra-articular BPC-157 injection for chronic knee pain