The lipases comprise an active site based around a serine-histidine-aspartate triad (Ser144-His257-Asp203 for RML, Ser146-His258-Asp201 for TLL) with substrate access regulated by conformational changes involving a helical lid motif (Fig
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Physical symptoms of anxiety include persistent restlessness or feeling on edge, increased heart rate or palpitations, rapid breathing or shortness of breath, excessive sweating, trembling or shaking, muscle tension particularly in the neck and shoulders, gastrointestinal disturbances such as nausea or diarrhea, and sleep disturbances including difficulty falling or staying asleep
Changes in eating patterns and caloric intake frequently accompany GLP-1 therapy, as these medications significantly reduce appetite and promote satiety
Qualitative data were expressed as absolute frequency (N) and percentage (%)
Long-term injectable safety data are lacking