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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)

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Additionally, GLP-1 RAs should be considered in overweight or obese patients to reduce weight (class IIa, level B)

p = 0.04), homocysteine (from 16.2 2.9 mol/L to 13.3 3.0 mol/L

The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake

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