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Nowadays, there are 1 billion people encountering over-weight problem, and 30 million people are diagnosed of obesity

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In more severe cases, clinically significant interstitial nephropathy develops, mediated by deposition of MSU crystals in the physiologic pH milieu of the renal medullary interstitium (a condition termed gouty nephropathy, which impairs renal function)

The others have compelling anecdotal data and decent mechanistic logic, but far fewer robust human trials for fat loss specifically