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47 : 235248 Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ, Muenz LR

Lewis JE, Kemp ML

The combination of all four pathways should theoretically produce earlier onset of appetite suppression, more sustained fullness between meals, increased resting energy expenditure from the glucagon component, and a reduced tendency toward the metabolic adaptation that commonly causes weight loss plateaus on single-agent therapy

An intradermal test dose is recommended before administration in patients suspected of being sensitive to the drug

People with past or present history of anxiety, depression, or mood disorders should be cautious and see a doctor if issues arise

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