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The multifaceted nature of overweight and obesity intertwines with various comorbidities, including cardiovascular diseases, type 2 diabetes mellitus (T2DM), musculoskeletal disorders, and certain cancers, thereby underscoring the imperative for effective management strategies [2]

Compared to BID exenatide, Exenatide LAR demonstrated a more significant decrease in HbA1c (1.9% versus 1.5%), accompanied by a comparable reduction in body weight (3.6 kg versus 3.7 kg)

Bevacizumab was the first anti-angiogenic drug used in patients with RCC, followed by VEGFR inhibitors such as sunitinib, sorafenib, pazopanib, cabozantinib, and axitinib (101)

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Animal studies report a plasma half-life around 4 hours after intraperitoneal administration