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doi: 10.3389/fphar.2017.00230 33 AminNBoccardiVTaghizadehMJafarnejadS

The results from this study indicated that astrocyte-targeting strategy (AST) clearly protected neurons from MPTP neurotoxin in both the young and aged groups, while the effect of AST was less pronounced in older mice, since it could not prevent the decrease in tyrosine hydroxylase (TH) in the nigrostriatal pathway (Grimmig et al., 2018)

(The FDA does not evaluate compounded medications for safety, quality, or efficacy before they are sold.) I think the compounders have a real valid argument, MacArthur says

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Moreover, as the catalytic pockets of tyrosinases have been reported to exceedingly conserved across the diverse species 5 and mammalian tyrosinase crystal structure is not available yet, homology model of human tyrosinase (UniProtKB-P14679) was collected from AlphaFold database ( 39 and aligned with the 3D crystallographic structure of mushroom tyrosinase (mh-Tyr) using Superimpose tool in the Maestro v12.6 tool of Schrdinger suite-2020.4 40