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At a glance Drug / isotretinoin (Accutane), oral retinoid for severe nodular acne Supplement / green tea extract (GTE), standardized to EGCG (epigallocatechin gallate) Primary concern / additive hepatotoxicity at GTE doses 400 mg EGCG/day Secondary concern / CYP1A2 and CYP3A4 modulation may shift isotretinoin metabolism Dietary green tea risk / low, typical brewed cup contains 50 to 100 mg EGCG Monitoring required / LFTs (ALT, AST) at baseline and weeks 4, 8 per iPLEDGE protocol FDA DILI signal / GTE linked to drug-induced liver injury in 29 case reports reviewed by NIH LiverTox Recommendation / avoid concentrated GTE supplements during isotretinoin

Chronic Liver Diseases Morbidity and mortality of chronic liver diseases (CLD) increase rapidly worldwide

UK Researchers are excited about the potential of these peptides to treat a wide range of conditions, from tissue injuries and skin regeneration to metabolic disorders and muscle wasting

doi: 10.1111/bjh.12959 214

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Improved Detoxification Supports liver health and efficient toxin elimination