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they influence multiple molecules that cells use for energy production, antioxidant defence and tissue repair

Furthermore, NAMPT-mediated NAD + biosynthesis and sirtuins in the intestine are critical for intestinal homeostasis, including GLP-1 production [39]

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Diarrhea or Constipation Because GLP-1 slows digestion, it may alter bowel habits

The measurement of paracellular permeability is usually quite straightforward since the movement of ions and charged organic molecules can be measured as an electrical current and the movement of neutral molecules can be measured by assaying their concentration in the bloodstream or urine or in a compartment equivalent to the subepithelial space in mounted or perfused tissue or in cultured cells grown on permeable substrates