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Based on the aforementioned studies, we were motivated in this experimental model to investigate the possible protective effects of EMPA pretreatment (1 and 3 mg/kg) against PTZ-induced seizures in rats using the win-PTZ kindling method and to figure out the mechanism that may underlie its antiepileptic effect and the implication of the BDNF pathway in an attempt to provide a new therapeutic venue for EMPA as a neuroprotective drug that may target the process of epileptogenesis

The maximum plasma concentration (C max ) reached for a standard dose of PZQ (1,500 mg), in healthy volunteers, is 0.16 g/ml or 513 nM 64