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Since expression of peripherin is not fully exclusive for the PNS, we further cannot exclude the possibility that GIPR was also deleted in our studies in peripherin-expressing neurons outside the PNS

HF severity is characterized by the increase in inflammation [108], where the use of SGLT2is increases the circulating levels of -hydroxybutyrate, which is an effective blocker of the NLRP3 inflammasome-mediated inflammatory process, which plays an important role in mediating inflammation [110,111]

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Efforts continue to refine receptor targeting