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Chronic stress can contribute to various health issues, including PHG, and can manifest as sleepless nights, anxiety, loss of appetite, and high blood pressure

Consequently, the regulation of mitochondrial function over the course of ASD pathogenesis and pathophysiology may be intimately linked to alterations in the interactions of the serotonergic and melatonergic pathways

& Zimmerman, T

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While the 28-day treatment period and use of only male rats were consistent with standard protocols to reduce variability in early-phase toxicological studies, these choices limit the extrapolation of our findings to chronic exposure scenarios and across sexes