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How Semaglutide Mimics Natural GLP-1 Semaglutide is akin to a bioidentical hormone because it closely replicates the action of the naturally occurring GLP-1 hormone: 1

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Louis Aronne, director of the Comprehensive Weight Control Center at Weill Cornell Medicine, told "GMA" that rebound weight gain can be common after stopping semaglutide because the drug is no longer working in the body