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For the case of such a small molecule as niclosamide, (V m = 202.53.0 cm 3 , ACD/iLabs) and a low topological polar surface area of 95.15 2 (Drugbank), (where any value below 140 2 is considered hydrophobic enough to partition into the membrane interior), it is well within the parameters for membrane partitioning

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Del Corral, T

IV treatments are expensive, time-consuming, and require a clinical setting

Boura, E., Rezabkova, L., Brynda, J., Obsilova, V