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Final Verdict: Are Peptides Safe According to Current Research

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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

(2025) 10:e183706

It does so by reducing melanin production through the inhibition of the enzyme tyrosinase, and by converting eumelanin (dark pigment) into pheomelanin (a lighter, reddish-yellow pigment)