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additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable
UrbanCHayesHVPirainoGWolfeVLahniPOConnorMet al
In a recent in vivo study utilizing an aging mouse model of IBD, chronic colitis triggered spatial and memory deficits (He et al., 2021)
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