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While the scopolamine model is often used to assess the cognitive enhancing capacity of experimental molecules it clearly initiates learning deficits in a non-physiological manner that only results in acute deficits

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Introduction: The Testing Framework for Nasal Drug Products Nasal sprays are a clinically important and commercially significant dosage form delivering active pharmaceutical ingredients directly to the nasal mucosa for local effects (treating allergic rhinitis, nasal congestion, sinusitis) and systemic absorption (delivering drugs via the highly vascularized nasal epithelium, bypassing first-pass hepatic metabolism)