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GLP-1 weight-loss drug popularity reaches new heights with Americans It's been about five years since the U.S

The most expensive pills are Slynd, a name-brand progesterone-only pill that costs $290/pack

GLP-1s, such as exenatide and liraglutide, enhance the activity of GLP-1 receptors, thereby stimulating insulin secretion, suppressing glucagon release, and slowing down the emptying of the stomach

Last reviewed: April 21, 2026 Updated with Phase 3 TRIUMPH-4 data Primary sources: NEJM, Eli Lilly, ClinicalTrials.gov Retatrutide is a triple agonist (GLP-1 + GIP + glucagon) currently in Phase 3 trials, showing stronger early weight loss data

Charrier, A

How it works in the real world could be different, says Dr