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The choice of treatment varies depending on the patients condition, weight loss goals, side effect profile, cost, and preferred administration method

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Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents

Some protocols suggest 'testing' a degraded vial by injecting half the usual dose and monitoring for effect