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This could be attributed to location-specific functions that have been proposed for GLP-1, with ileal GLP-1 stimulating insulin release in response to nutrients (72) and colonic GLP-1 exerting rather local effects, i.e

Genetic Factors in Semaglutide Response and Muscle Biology Your likelihood of experiencing muscle cramps may reflect genetic variation in GLP-1 receptor expression and electrolyte regulation

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Shen and Pappano, 1995), most likely due to a greater LCAC to membrane phospholipid mole ratio (discussed later)