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The new findings highlight the importance of glutathione mobility within the cell and the direct interaction of glutathione-associated enzymes with viral factors or vRNA essential for the full-fledged development or initiation of viral infection (particularly through interactions with UTR sites in vRNA)

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318,319,320 Furthermore, stability can be improved without compromising drug activity by optimizing the number and modification positions of 2-F and 2-OME groups on both strands of double-stranded siRNA, leading to substantial efficacy improvements