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doi: 10.3389/fphys.2021.751501 59 RogerioAPFontanariCBorducchi.KellerACRussoMSoaresEGet al

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The risk of injecting denatured proteins, impurities, or bacterial contamination is extremely high

Many patients experience poor efficacy and adverse reactions when using these drugs [2]

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This is the central limitation of the evidence base, and any honest discussion has to start there