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because rigorously controlled human safety data specific to the TB-500 fragment does not exist, its longer-term risk profile, including possible immune reactions, remains unknown Evidence snapshot: Evidence for TB-500 itself is preclinical, drawn mainly from cell-culture and animal studies (a 1999 rat wound-healing study and later rodent cardiac- and tendon-injury models), with a 2026 scoping review describing the musculoskeletal literature on thymosin beta-4 and TB-500 as sparse and largely preclinical

Robot Auton Syst 121:103253 Li S, Li J, Tian G, Shang H (2019b) Stiffness adjustment for a single-link robot arm driven by series elastic actuator in muscle training

Each brain region was considered as a sub-study, as each region of interest constitutes an individual MRI experiment, although this increases the n and thus decreases variance since a publication can appear more than once

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