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Unlike the potent TGR5 agonists, DCA and LCA, we could not detect any effects of TMCA on cAMP levels in the STC-1 cells, NCI-H716 cells, and mouse intestinal organoids, suggesting that the increased ileal TMCA observed in the mice after T3 treatment might not act via TGR5-mediated pathway

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The lyophilized form demonstrates strong stability when stored correctly under standard laboratory conditions

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In a head-to-head comparison, tirzepatide users lost an average of about 20% of body weight over 72 weeks, versus roughly 15% with semaglutide (source: NEJM)