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Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey

The participant may have a unique skin microbiome profile Antedotal case studies of B12 supplementation and acne development There are a few cases of individuals developing acneiform eruptions after B12 supplementation

A healthcare provider must evaluate your overall health and history to decide if medication is right for you

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Experience to date has shown that higher amounts used have no adverse effects on the unborn child

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